Clinical Strategies for Determining Effectiveness of Various Antiaging Skin Care Products
Nalini Kaul and Elsie Kohoot, Hill Top Research, Poster No. P211, American Academy of Dermatology, (San Antonio, TX, February 2008).
ABSTRACT
The demand for antiaging skin regimens is at an all time high. Antiaging facial skin care products - lotions and creams - work on facial lines, crow's feet, fine lines and wrinkles. Other aging concerns include skin surface dryness, roughness, dullness, laxity, skin tone, hyper and hypo pigmentation and overall appearance of the skin. Antioxidants (AO), vitamins, omega 3 fatty acids, alpha lipoic acid, neuropeptides and others are becoming increasingly incorporated into facial creams and lotions for improved clinical performance. Our primary aim was to capture photoaging characteristics and provide testing strategy for antiaging facial regimens by checking for improvement with these products. Current strategies involve enrollment of healthy female subjects (35-60 years) who give signed informed consent. Subjects are screened for extent of photodamage and those with mild to moderate overall photodamage meeting study criteria are enrolled in clinical trials from 4-12 weeks. Subjects in the clinical trial presented here were asked to use the antioxidant rich antiaging regimen twice daily for the entire duration of the study. Measurements included clinical visual assessments by a blinded expert evaluator, subjective assessments, silicon replicas and digital photographs at baseline, midpoint and at the end of the clinical trial. Our results based and supported by scientific testing and clinical assessments, provide insight into product efficacy, safety and consumer acceptance by tracking of photoaging skin characteristic changes.
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